Cancer Treatment With Fenbendazole

The anti-parasitic drug mebendazole has a similar mechanism to some anticancer drugs and may help prevent cancer cells from growing, according to a study published in the journal Oncotarget. The drug, also known as fenbendazole, is used to fight roundworms and hookworms by cutting off their supply of nutrients. It acts by collapsing tubulin, which forms the structure of the inner cell and is a highway for transporting food into the parasites.

The research was led by Gregory Riggins of McMaster University’s Centre for Discovery in Cancer Research. The team studied mice that were genetically engineered to develop pancreatic cancer. They found that fenbendazole reduced the size of tumors and inhibited their growth. Riggins says that he and his team are investigating whether mebendazole can slow or stop the development of human cancer in clinical trials.

Benzimidazoles have been shown to be effective in preventing microtubule polymerization by binding to tubulin and thereby disrupting its assembly process. Fenbendazole is a broad-spectrum benzimidazole and has been approved for use in many animal species. Repurposing veterinary drugs that are safe in animals may reduce the time and cost required to develop new medicines.

We investigated the effects of fenbendazole and the mTOR inhibitor rapamycin in combination on HeyA8 cell line proliferation in vitro by using a clonogenic assay. Micelles encapsulating fenbendazole and rapamycin were prepared at various ratios, and synergistic effects were observed in several combinations. The fenbendazole/rapamycin micelles (M-FR) showed better colony inhibition than the free drug and released the drug more slowly than the fenbendazole alone. fenbendazole cancer treatment

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